
The game received critical acclaim on release, and was praised for its humor, voice acting, graphics, music and gameplay. The game was one of the first to incorporate full voice talent the two title characters were voiced by professional voice actors Bill Farmer and Nick Jameson while additional voices were provided by Irwin Keyes, Marsha Clark, Denny Delk, Tony Pope and Beth Wernick. Sam & Max Hit the Road is the ninth game to use the SCUMM adventure game engine, and also integrated the iMUSE audio system developed by Michael Land and Peter McConnell. Series creator Steve Purcell, then a LucasArts employee, was one of the lead designers on the project. LucasArts began development of the game in 1992 with the intention to use new settings and characters after the success of the past Maniac Mansion and Monkey Island adventure titles. Based on the 1989 Sam & Max comic On the Road, the duo take the case of a missing bigfoot from a nearby carnival, traveling to many American culture tourist sites to solve the mystery. The characters, created by Steve Purcell, originally debuted in a 1987 comic book series.

The game is based on the comic characters of Sam and Max, the "Freelance Police", an anthropomorphic dog and "hyperkinetic rabbity thing".

A 2002 re-release included compatibility with Windows. The game was originally released for MS-DOS in 1993 and for Mac OS in 1995. Sam & Max Hit the Road is a graphic adventure video game released by LucasArts during the company's adventure games era.
